A novel <sup>18</sup>F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET <i>in vivo</i>
نویسندگان
چکیده
In this work, high-contrast PET imaging of subcutaneous SNAP-tag expressing tumor xenografts is achieved by bioorthogonal covalent targeting with a novel 18 F-based radioligand in vivo .
منابع مشابه
Fluorescent labeling of COS-7 expressing SNAP-tag fusion proteins for live cell imaging.
SNAP-tag and CLIP-tag protein labeling systems enable the specific, covalent attachment of molecules, including fluorescent dyes, to a protein of interest in live cells. These systems offer a broad selection of fluorescent substrates optimized for a range of imaging instrumentation. Once cloned and expressed, the tagged protein can be used with a variety of substrates for numerous downstream ap...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2021
ISSN: ['1359-7345', '1364-548X']
DOI: https://doi.org/10.1039/d1cc03871k